Oncology services

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. We offer a state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facilities, Karolinska Experimental Research and Imaging Centre (KERIC) and the MRI Centre, aim to catalyse novel and translatory research using MRI. At KERIC, we offer a 9.4T MRI for animals such as rabbits and small piglets (see service for small animal 9.4T MRI). A state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients are available for large animal preclinical studies. We offer specialised services for large animal models as well as ex vivo imaging and support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits, module technical support and animal technicians. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc Or https://imagingresearch.se/facilities/corefacilities/keric

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. A unique next-generation clinical 7 Tesla Siemens MAGNETOM Terra.X. equipped with an ultra-high field scanner also offers cutting-edge gradient performance (130 mT/m at 250 T/m/s), parallel transmission, as well as deep learning-based acceleration and denoising for improved image quality. Micrometre resolution in vivo for microstructural imaging and layered fMRI. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), we have a preclinical 9.4T Bruker USR 94/30 MRI system. The state-of-the-art 9.4T MRI is equipped with single-mouse, single-rat, or double-mouse beds. It has three gradient bore sizes to arrange an effective inner diameter of 20cm (large animals), 12cm (medium animals) or 6cm (small animals). Methods in anatomical imaging, fMRI, Ex vivo, Pharmacological MRI and Cardiac imaging (CINE). For the mouse brain, a 4-channel phased array cry-coil drastically increased signal-to-noise. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/keric

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Access to compound collection https://www.cbcs.se/the-compound-collection The Scilifelab Compound Collection is managed by the Compound Center at CBCS KI, and is based on donations of high-quality sets from the pharmaceutical industry (Biovitrum, Karobio, Orexo/Biolipox, KDev) and has been developed and expanded with compounds from various commercial compound vendors. The compounds can be readily available in assay-ready plates through acoustic nano-litre scale liquid dispensing or in 96-tube racks; compounds are stored at 10mM concentration in DMSO solution at - 20 °C under humidity control. We provide: o Management, storage, and processing of solids and liquids. o Compound delivery and interface with key customers. o Performance of instruments and automation that support these operations. o Analytical techniques used for quality assurance. o Sample informatics, including registration and compound quality data.

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Anatomic pathology slides: preparation +/- associated patient clinical data +/- analysis +/- software evaluation +/- medical expertise; cancer, lesion, sample, biopsy, tissue, organ; histology, diagnosis, genetic; microscope, scanner

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Assay development & highthroughput screening We provide expertise and technical support in the following areas: o Access to small-molecule compound libraries and robotic instrumentation. o Expertise in assay development and automation. o High-throughput screening: biochemical target-based, cell-based and phenotypic. o High-throughput imaging technology. o Computational chemistry and modelling. o Medicinal chemistry expertise. o Chemical Biology Platform. Perspective use case: Purpose The Cell Painting technology can be used to visualize many cellular parameters simultaneously, using organelle-specific fluorescent dyes and high-content imaging. This approach allows you to systematically visualize how cell morphologies react to certain stimuli, like chemical perturbations. It is thus possible to foresee in the near future that the CP technology is a valuable technology to create large systematic AI minable cell morphology resources and customized validation data sets for profiling small molecules and other treatment modalities. Development of new AI software for morphology profiling, cell segmentation for validation sets for functional perturbation assays are needed for future precision medicine. Description of service/ technology: Cell painting, high-content imaging, high-throughput screening Drug library design and delivery, cell culture and immunofluorescence staining Dataset generation, data analysis AI software development Expected outcome: New dataset generation to train AI algorithm on the different type of images generated. Improvement of AI algorithm.

Centre D'Excellence En Technologies De L'Information Et De La Communication (CETIC)

The collection of data from various sources (devices, files, interconnected services, etc.) is a complex step and typically falls outside the core business of medical sector companies, which aim to focus on the analysis of this data. How can the service help you? The CETIC provides access to a highly customizable catalog of tools for engineering medical data collection, storage and analysis. These tools enable : (a) automation of the collection of heterogeneous medical data from virtually any type of source (like IoT, API, files, remote repositories or databases, propriatary equipments, etc.) and its mapping to fully-customisable data representations enriched with semantics (DMWay tool) (b) a scalable and persistent data storage (c) easy yet powerful data analysis (TSANO tool) How the service will be delivered? It depends on the customer's need Method reference: https://asset.cetic.be/en/dmway/ https://www.cetic.be/analyse-prescriptive-au-service-de-industrie40

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Kit preparation; reception of sample +/- inventry +/-relabelling +/- entry of additional medical data +/- managing of consents; aliquoting; ficoll; cell count viability; extraction (RNA, DNA); freezing and conservation (-150°C, -80°C, -20°C, +4°C, nitrogen); cell culture and maintenance; preparation of parafin from fresh or frozen tissues; biobank, biological sample, aliquot, storage, tissue, cell, blood, urine

Univerzita Komenskeho V Bratislave (UK BA)

Expertise in vitro cultivation various types of cells (human and animal), molecular analysis, imaging protocols and analysis, study design, full service measurement, academic applications. Cell culture laboratory equipment includes BSL-2 flow boxes, CO2 incubators, light microscope, cell counter; molecular laboratory equipment (RT-PCR thermocyclers, agarose/SDS-PAGE apparatus and Western blot transfers, Elisa plate reader), cellular analysis (cellular processes analyzer, fluorescent microscopy scanner.

Fondation De Cooperation Scientifique (IHU STRASBOURG)

• Submission to the French regulatory authorities (Ethical committee CPP, ANSM). • Feedback management with these regulatory authorities to take into account their requirements.

Fondation De Cooperation Scientifique (IHU STRASBOURG)

• Clinical investigation set-up of the with patient inclusion, patient follow-up, data collection, queries management, ... • Clinical investigation coordination (mono-centric or multi-centric). • The IHU may be the sponsor or an associated investigation center.

Fondation De Cooperation Scientifique (IHU STRASBOURG)

eCRF, DMP, DVP

Fondation De Cooperation Scientifique (IHU STRASBOURG)

• Discussion of the SME needs and suggestions. • Technical feasibility according the medical device maturity

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Writing the documentation dedicated to the clinical investigation and needed for the regulatory submission: protocol, patient information letter. Support to the technical file writing (including the investigator brochure) under the manufacturer responsability.

Fondation De Cooperation Scientifique (IHU STRASBOURG)

• Definition of the SME needs and suggestions. • Access to expert medical opinion. • Definition of the clinical investigation methodology (number of subjects, study design, endpoints definition...) • Budget proposal for the clinical investigation. Support to funding research

Fondation De Cooperation Scientifique (IHU STRASBOURG)

• Assisting SMEs in regulatory submissions in compliance with applicable laws and requirements • Providing SMEs with the necessary regulatory documents • Liaison with regulatory bodies: Ethics Committees (EC), National Agency of Drugs Safety (ANSM)

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Journals, Meetings, Events

Univerzita Komenskeho V Bratislave (UK BA)

(1) The laboratory provides microsatellite instability (MSI) in FFPE cancer tissue in low throughput screening methods, including PCR and fragment analysis. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing in GeneMapper v.6 software. (2) Next, the laboratory provides DNA methylation analysis in promoter regions of genes in low and medium throughput screening methods, including pyrosequencing and/or MS-MLPA and fragment analysis. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing in Cofalyser.net softvare. (3) The laboratory also provides comparative genomic hybridization (CGH), as well as single nucleotide polymorphism (SNP) detection by microarray that enables identification of aneuploidies, microdeletions, microduplications, as well as other types of chromosomal aberrations across the genome. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing. (4) The laboratory provides detection of single nucleotide variation from various types of samples by real-time PCR or Sanger sequencing. The method is also usefull for verification of whole genome sequencing results. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing. (5) The laboratory also provides targeted sequencing of selected parts of the genome (e.g. TruSight Oncology 500 panel), followed by somatic or germline analysis. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing in Pierian software with clinical interpretation.

Karolinska Institutet (KI)

This service is a follow up to the Data Feasibility Study, and can only be delivered after that service has been completed and a potential data set that meets the requirements has been identified. Note that an additional fee, not covered by the call's price reduction, may apply. ## Overview Acquiring existing data sets—full-service data management. This service makes data sets identified in the Data Feasibility Study available to SME’s for TEF-project purposes, such as validation and testing of AI systems. Data can be collected from routine health records and local, regional, and national databases in collaboration with healthcare providers in Sweden. We provide expertise and technical support in the following areas: • Project design & management • Ethical application support • Data assembly • Data cleaning, annotation, anonymisation or pseudonymisation ### How can the service help you? Access to existing health data can help you validate your AI solution without needing to generate new data. We provide access to high quality datasets for validation and testing of your AI system, to facilitate placing it on the market and to increase its market readiness level, for example by supporting regulatory approval and building stakeholder/healthcare-provider confidence. Validation and testing data can be used for independent performance evaluation of your AI system in a real-world or simulated environment. Validation and testing without needing to generate new data frees up time to focus on model optimization and deployment. ### How will the service be delivered? The service will be delivered according to established ethical agreements and guidelines, in collaboration with the SME and researchers from the Swedish TEF-Health node. Data usage is facilitated through a secure virtual environment managed by Karolinska Institutet, ensuring the highest standards of data protection. --- ## Additional information ### Provider description The Swedish TEF-Health node is a collaboration between Karolinska Institutet, SciLifeLab and RISE, and is led by Karolinska Institutet. Together, we offer world-leading services with our unique collection of core facilities. We grant services in expert consulting, virtual- and physical testing in the range of in vivo imaging, ex vivo OMICS, pharmaceutical development, simulated healthcare environments, AI-system validation and development, advanced data analysis and other data-driven life science. ### Technical description Datasets identified in the Data Feasibility service will be made available to suit your AI system, supporting the testing and validating of your solution. The data will be tailored to your specific request to ensure it is compatible with your AI system and its real-world use, and with full support from Karolinska Institutet to ensure compliance with all relevant regulations, including GDPR and national Swedish regulations. Upon completion of this service, you will receive an evaluation of the performance of your AI system. ### Service customization The service can be customised according to your specific needs, taking into account which type of data you require. --- ## Use case example An SME developing an AI-based diagnostics system requests access to the retrospective datasets identified in the Data Feasibility Study service to independently validate the solution. Under an ethical agreement with the Swedish TEF-Health node, the service assembles and prepares the data and provides access through a secure virtual environment at Karolinska Institutet, where the system is tested in simulated and real-world scenarios. The resulting performance evaluation demonstrates the system's accuracy and reliability, supporting the SME's regulatory approval process and market entry.

Eucaim

Cancer Image Europe provides a robust, trustworthy platform for researchers, clinicians, and innovators to access diverse cancer images, enabling the benchmarking, testing, and piloting of AI-driven technologies. EUCAIM Platform integrates a dashboard, a catalogue and a federated searching environment to discover Medical Imaging data related to cancer from a distributed federation of data holders. EUCAIM provides in some nodes processing capacity to securely access the data. EUCAIM is mainly intended for Data scientists to develop, validate or improve AI models or image postprocessing tools. The platform is accessible in https://dashboard.eucaim.cancerimage.eu/

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Rental of the simulated OR and the image acquisition devices : Artis Zeego (pricing doesn't include human resources that must be present in support)

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Rental of the simulated OR and the image acquisition devices : CT SCAN (pricing doesn't include human resources that must be present in support)

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Rental of the simulated OR and the image acquisition devices : MRI (pricing doesn't include human resources that must be present in support)

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Rental of the simulated OR and the image acquisition devices : US, (pricing doesn't include human resources that must be present in support)

Univerzita Komenskeho V Bratislave (UK BA)

Laboratory infrastructure includes flow cytometer/sorter FACS Aria II c, fluorescence microscope Olympus iX72, light microscope, BSL-2 laminar hoods, cell incubators, and electrophoretic equipment for Western blot. The laboratory develops and prepares unique in vitro models (3D and 2D cancer cell lines) derived from human tumor tissue.

Hospices Civils De Lyon (HCL)

Formative evaluation of surgical robot prototype (under development) in order to improve usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including design improvement recommendations and potential new use-related risks to mitigate Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of AMR (Autonomous Mobile Robot) for logistics: - performance and acceptability in realistic environment with representative users This packaged service includes : - Room rental for testing - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of surgical robot prototype in order to assess : - performance in realistic settings (using phantoms) - technical integration within operating theatre (interoperability, space constraints, etc.) This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Test and validtation by users in simulated or real OR environment of your medical device

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Clinical acquisition of images in an OR using different imaging modality : -US -EUS -Endoscopy -MRI -CT SCAN -Artis Pheno *Clinical data collection must be included in a clinical study that IHU can design according to your needs*

Univerzita Komenskeho V Bratislave (UK BA)

Cell microscopy - Confocal laser scanning microscop Zeiss LSM 880 (Fluorescence microscopy, Real-time recording, Time-resolved microscopy, Whole tissue scanning, Image processing)

Univerzita Komenskeho V Bratislave (UK BA)

Small animal MRI imaging: Bruker BioSpec 70/20 USR 7 T preclinical (MRI, MRS, MRSI, relaxometry, iron quantification, Image processing and analysis)

Fondation De Cooperation Scientifique (IHU STRASBOURG)

Preclinical acquisition of images in an OR using different imaging modality : -US -EUS -Endoscopy -MRI -CT SCAN -Artis Zeego *Preclinical data collection must be included in a preclinical study that IHU can design according to your needs*

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Neuro Imaging platform includes: -MEG/EEG (Elekta Neuromag) : 204 gradiometers, 102 magnetometers, 128 EEG channels. - MRI/MEG-compatible EEG amplifier (Brain Products) : 64 channels. - MRI 1.5T (Siemens Espree) - Audio, visual and sensitive stimulation equipment - Dedicated HPC workstation for real-time signal processing The service offers to conduct a clinical study with MEG/EEG/MRI Imaging to generate new brain-related data: - Data acquisition & analysis +/- technical expertise. - Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. - Example: provide new clinical data to assess/validate the performance/robustness of an AI system in a specific intended use Keywords: Neuro Imaging; MRI; MEG; imaging data acquisition

Univerzita Komenskeho V Bratislave (UK BA)

Laboratory provides low or medium throughput screening of selected bacterial and/or viral strains from various sample material, including sample preparation to analysis by real-time PCR. The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing.

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Motion laboratory rental for prototype testing : usability/technical testing and evaluation of medical device [no patients included]. Examples: Study of an exoskeleton's movements ; analysis of "fine" surgical robots mouvements. Motion lab equipped with: - 8 infrared cameras, 2 high-resolution cameras, 2 plantar pressure sensors - Wireless pressure sensors and non-invasive electromyographic sensors (system Cometa) - GAITrite system (Spatio-temporal gait parameter analysis system) - Dedicated workstation and data-storage for daily-use analysis Keywords: motion; rental; technical testing; medical device evaluation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Within the motion analysis laboratory, this service can offer: 3D motion analysis system: - full body motion analysis - Gait analysis thanks to a full GAITrite system - definition of an anatomical model - motion sequence validation with an exoskeleton - movement tracking of robotics Data acquisition can be completed with data analysis service. Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. Examples: clinical study to validate an exoskeleton on patients ; to validate a rehabilitation device on patients, ... Keywords: motion; GAIT analysis; robotics; exoskeleton; medical device validation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Neuro Imaging platform includes: -MEG/EEG (Elekta Neuromag) : 204 gradiometers, 102 magnetometers, 128 EEG channels. - MRI/MEG-compatible EEG amplifier (Brain Products) : 64 channels. - MRI 1.5T (Siemens Espree) - Audio, visual and sensitive stimulation equipment - Dedicated HPC workstation for real-time signal processing The service offers to conduct a clinical study with MEG/EEG/MRI Imaging to generate new brain-related data: - Data acquisition & analysis +/- technical expertise. - Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. - Example: provide new clinical data to assess/validate the performance/robustness of an AI system in a specific intended use Keywords: Neuro Imaging; MRI; MEG; imaging data acquisition

Univerzita Komenskeho V Bratislave (UK BA)

Full-service metabolomics analysis in-vitro and ex-vivo using NMR spectroscopy. Proficiency in instrumentation performance, metabolomic measurement protocols and data analysis for clinical, academic and indystry applications.

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Non-human genome sequencing Sequencing of bacterial or viral whole genomes with the possibility of sequence analysis and strain typing. Sequencing of SARS-CoV-2 amplicons. Sequencing of metagenome samples (with PCR-free protocol). This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA& RNA sequencing (microbial genomes, metagenomics) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Open access to instrumentation Possibility to rent specialised laboratory equipments, and also to get your own equipment tested by our team of scientists and lab experts. Scientific writing support and reporting can also be offered if needed.

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Conduct an interventional clinical study within clinical research facility CEA-Clinatec : Operating room and hospitalisation room, with access to Grenoble-Alpes University Hospital's network of clinicians. Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. Operating room equipped with: - Neuro navigation robotic system ROSA - Intraoperative 1,5T MRI (Espree, Siemens): positioned on a rail to go into the operating room during surgery - Mobile X-ray unit (general Electric) - Stereotaxis interventional radiography chain (Apelem) Keywords: operating room; clinical study; surgery; neurology; medical device validation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Facility rental for: - protoype testing: usability/technical testing and evaluation of medical device [no patients included] - MRI compatibility evaluation of medical devices Rental of the operating room including: - surgical and anesthesic equipment MRI-compatible - anesthesic area - hospitalisation rooms if needed OR equipped with: - Neuro navigation robotic system ROSA - Intraoperative 1,5T MRI (Espree, Siemens): positioned on a rail to go into the operating room during surgery - Mobile X-ray unit (general Electric) - Stereotaxis interventional radiography chain (Apelem) Keywords: operating room; medical device evaluation

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - MedTech & AI Companies: For obtaining high-quality, ethically sourced clinical datasets to fuel algorithm development without navigating hospital bureaucracy. - Clinical Researchers: For systematic, regulation-compliant data collection with full documentation and audit trail. **Key Features:** - End-to-end management of ethical approval processes (ethics committee submission, informed consent design) - Prospective data collection within Universitätsklinikum Erlangen clinical departments - Expert clinical annotation and ground truth labeling by domain specialists - Full GDPR compliance with pseudonymization/anonymization pipelines - Structured data output compatible with downstream AI training and analysis workflows **Possible Applications:** - Wearable Sensor Studies (e.g. Cardiology): Prospective collection of continuous ECG, PPG, or blood pressure data from cardiac patients for digital biomarker development and remote monitoring algorithm training. - Motion & Gait Analysis (Biomechanics): Systematic acquisition of IMU, force plate, and motion capture data in clinical and sports lab settings for movement disorder assessment, rehabilitation tracking, or athletic performance evaluation. - Neurological Signal Acquisition: Collection of EEG, EMG, or tremor sensor data from neurological patient cohorts to support AI-based diagnostic or therapy monitoring tools. - Real-World Evidence Datasets: Longitudinal data collection from ambulatory patients in everyday settings, enabling the development of algorithms that generalize beyond controlled lab environments. - Athletic Performance & Injury Prevention: Structured data gathering during sports science testing protocols to build datasets for injury risk prediction, load monitoring, and return-to-play decision support. - Multi-Modal Clinical Datasets: Combined collection of sensor data, imaging, lab values, and patient-reported outcomes to enable holistic, multi-modal AI model development. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, the Brain Molecular Imaging Centre (BMIC), supports clinical and pre-clinical research studies involving PET experiments. For large animal preclinical studies: the GE Discovery MI 5 PET/CT is a whole-body PET system designed for increased field of view to enable exceptionally high sensitivity, allowing AI, deep learning image reconstruction. The PET system is mainly used in humans and larger animals such as pigs. The system specifications are Transaxial FOV: 70 cm, Axial FOV: 25 cm, Spatial resolution: ~5 mm. Radiopharmacy CF, we then provide full service in conducting PET experiments. In this service, we offer our highly trained staff comprising PET camera operators, medical physicists, research nurses and physicians, as well as specialised staff conducting experiments with animals. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/bmic

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), has two PET-CT systems for animal imaging (Mediso nanoScan PET-CT). They are equipped with single-mouse, single-rat, or double-mouse beds. Four mice can be run simultaneously with exceptional image quality. The PET modules (spatial resolution 0.8mm) and a CT module (min. voxel size: 10-34 µm). KERIC collaborates closely with the Radio Pharmacy Core Facility (RCF), which allows us to deliver freshly produced radioactive ligands within a minimum time frame. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://ki.se/en/research/pet

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), we have a preclinical 9.4T Bruker USR 94/30 MRI combined with Mediso nanoScan PET-CT systems for small-animal imaging equipped with single-mouse, singe-rat, or double-mouse beds. The PET module has a spatial resolution of 0.8mm. The state-of-the-art 9.4T MRI is equipped with three gradient bore sizes to arrange an effective inner diameter of 20cm (large animals), 12cm (medium animals) or 6cm (small animals). Methods in anatomical imaging, fMRI, Ex vivo, Pharmacological MRI and Cardiac imaging (CINE). For the mouse brain, a 4-channel phased array cry-coil drastically increased signal-to-noise. KERIC collaborates closely with the Radio Pharmacy Core Facility (RCF), which allows us to deliver freshly produced radioactive ligands within a minimum time frame. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/keric

Karolinska Institutet (KI)

The Swedish node is a collaboration between Karolinska Institutet, SciLifeLab and RISE. Together, we offer world-leading services with our unique collection of core facilities. We can grant services in expert consulting, virtual- and physical testing in the range of in vivo imaging, ex vivo OMICS, pharmaceutical development, simulated healthcare environments, AI-system validation and development, advanced data analysis and other data-driven life science. Prospective data set collection: A full-service collection of new data sets. This service serves to create data sets on-demand according to the needs and requirements of the SME for TEF-project purposes, such as validation. Data sets will primarily comprise in vivo imaging data (PET, CT, MRI, MEG, EEG), ex vivo imaging, and OMICS data within neuro and cancer. Data can be generated by CIR and SciLifeLab infrastructures within our “Physical Testing” services or assembled from publicly available databases and research collaborations. We provide expertise and technical support in the following areas: o Project design& management o Ethical application support o Data collection o Data assembly o Data cleaning, annotation, anonymisation This service can typically directly collaborate with “physical testing services” and technology infrastructures to generate raw data material.

Univerzita Komenskeho V Bratislave (UK BA)

The laboratory provides detection of RNA expression in low, medium and high throughput screening methods, including real-time PCR or microarray (MA). In additon, it provides detection of miRNA expression in low, as well as in high throughput screening meethods, including real-time PCR (qPCR) or microarray (MA). The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing.

Fondation De Cooperation Scientifique (IHU STRASBOURG)

8 clinical Operating Rooms 5 simulated Operating Rooms (preclinical)

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC) offers simulated environmental operating rooms for surgical training and medical and robotic device testing. KERIC is a joint university- and hospital facility that gives you access to expert surgeons, medical doctors, technicians and researchers expertise. The four operation units are equipped with: • Anaesthesia equipment (Dräger Primus Infinity) • Monitoring equipment (Datex / Philips MX800) • Operating table (TruSystem 7000) • Surgical diathermy (Valleylab, ForceTriad) • Surgical light (Maquet Volista) • Patient warming units (Mistral Air) • Surgical suction • Standard surgical instruments Our operating rooms are regularly used for surgical training in transplantation, neuro/stroke, pediatric surgery, specialist trauma expertise, otorhinolaryngology, gynaecology, and pediatric surgery. In this service, we offer full support in project consultation, ethical permits, module technical support, expert surgeons, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://ki.se/en/research/research-infrastructure-and-environments/core-facilities-for-research/keric/experimental-surgery

Hospices Civils De Lyon (HCL)

Rental of the surgical facility (130m²), including: - a simulated operating room, with audio-video recording of testing sessions - an observation room with audio-video controls - a meeting room for debriefing, focus group , etc. - a convivial space to welcome participants

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

This service provides 2 types of analysis: - Ex vivo imaging study : Multiplex spatial distribution of molecular species in biological tissue - Profiling study: multiplex analysis in complex biological samples. It includes: - Project design & feasibility study - Sample conservation, preparation and analysis using softwares such as Fleximaging & Flexcontrol - Data analysis with provision of a final report Examples: Evaluate or Compare AI system of an IVD-MD to mass spectrometric (MALDI) data of specific animal/human tissue Keywords: Mass Spectrometry; MALDI; ex vivo imaging study; profiling study

Hospices Civils De Lyon (HCL)

Summative evaluation of finalized surgical robot prototype (design freeze) in order to validate usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including root causes analysis of errors, close calls and use difficulties observed Prices range is indicative and depends on testing protocol complexity and particpants number

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Transcriptome sequencing (RNA-seq) Sequencing of mRNA (poly A based method) followed by fusion detection or germline analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o RNA sequencing (total RNA, mRNA) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Centre Hospitalier Universitaire De Grenoble (CHUGA)

Formative evaluation of medical devices: user testing of any medical device prototype in order to improve usability (according to IEC 62366-1). It includes: - writing protocols depending user profiles. - recruitment of required healthcare professionals and patients - rental of the operating room if needed - rental of phantoms - one or several iterative user testing steps and result analyses - evaluation report including ergonomic corrections and guidelines to bring to the medical device

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Whole genome or targeted DNA sequencing Sequencing of the entire human genome (with a PCR-free protocol) or selected parts of the genome (through exome or panel sequencing), followed by germline or somatic analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA sequencing (Whole Genome Seq (WGS), Whole Exome Seq (WES), Panels) o Bioinformatics (Bioinformatic analysis (data generated at CG) Equipment: Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio) Prospective Use case: AI based software solution uses WGS data to identify genetic biomarkers to help clinicians either during diagnostic phase and/or at the treatment phase in order to identify genetic aberrations possibly explaining the disease onset or to assist in the therapeutic decisions such as for example in breast cancer the presence of BRCA1 mutation. AI software can be trained to learn to deliver diagnostic based on WGS data (especially needed in the field of rare diseases) to recognize genetic variations (from single nucleotide to over 50bp deletion or insertion) in a more robust and accurate manner (to limit generation of false negative or false positive cases) to support clinicians in their decision process.