Cardiology services

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. We offer a state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facilities, Karolinska Experimental Research and Imaging Centre (KERIC) and the MRI Centre, aim to catalyse novel and translatory research using MRI. At KERIC, we offer a 9.4T MRI for animals such as rabbits and small piglets (see service for small animal 9.4T MRI). A state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients are available for large animal preclinical studies. We offer specialised services for large animal models as well as ex vivo imaging and support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits, module technical support and animal technicians. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc Or https://imagingresearch.se/facilities/corefacilities/keric

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. A unique next-generation clinical 7 Tesla Siemens MAGNETOM Terra.X. equipped with an ultra-high field scanner also offers cutting-edge gradient performance (130 mT/m at 250 T/m/s), parallel transmission, as well as deep learning-based acceleration and denoising for improved image quality. Micrometre resolution in vivo for microstructural imaging and layered fMRI. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), we have a preclinical 9.4T Bruker USR 94/30 MRI system. The state-of-the-art 9.4T MRI is equipped with single-mouse, single-rat, or double-mouse beds. It has three gradient bore sizes to arrange an effective inner diameter of 20cm (large animals), 12cm (medium animals) or 6cm (small animals). Methods in anatomical imaging, fMRI, Ex vivo, Pharmacological MRI and Cardiac imaging (CINE). For the mouse brain, a 4-channel phased array cry-coil drastically increased signal-to-noise. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/keric

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Access to compound collection https://www.cbcs.se/the-compound-collection The Scilifelab Compound Collection is managed by the Compound Center at CBCS KI, and is based on donations of high-quality sets from the pharmaceutical industry (Biovitrum, Karobio, Orexo/Biolipox, KDev) and has been developed and expanded with compounds from various commercial compound vendors. The compounds can be readily available in assay-ready plates through acoustic nano-litre scale liquid dispensing or in 96-tube racks; compounds are stored at 10mM concentration in DMSO solution at - 20 °C under humidity control. We provide: o Management, storage, and processing of solids and liquids. o Compound delivery and interface with key customers. o Performance of instruments and automation that support these operations. o Analytical techniques used for quality assurance. o Sample informatics, including registration and compound quality data.

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Assay development & highthroughput screening We provide expertise and technical support in the following areas: o Access to small-molecule compound libraries and robotic instrumentation. o Expertise in assay development and automation. o High-throughput screening: biochemical target-based, cell-based and phenotypic. o High-throughput imaging technology. o Computational chemistry and modelling. o Medicinal chemistry expertise. o Chemical Biology Platform. Perspective use case: Purpose The Cell Painting technology can be used to visualize many cellular parameters simultaneously, using organelle-specific fluorescent dyes and high-content imaging. This approach allows you to systematically visualize how cell morphologies react to certain stimuli, like chemical perturbations. It is thus possible to foresee in the near future that the CP technology is a valuable technology to create large systematic AI minable cell morphology resources and customized validation data sets for profiling small molecules and other treatment modalities. Development of new AI software for morphology profiling, cell segmentation for validation sets for functional perturbation assays are needed for future precision medicine. Description of service/ technology: Cell painting, high-content imaging, high-throughput screening Drug library design and delivery, cell culture and immunofluorescence staining Dataset generation, data analysis AI software development Expected outcome: New dataset generation to train AI algorithm on the different type of images generated. Improvement of AI algorithm.

Centre D'Excellence En Technologies De L'Information Et De La Communication (CETIC)

The collection of data from various sources (devices, files, interconnected services, etc.) is a complex step and typically falls outside the core business of medical sector companies, which aim to focus on the analysis of this data. How can the service help you? The CETIC provides access to a highly customizable catalog of tools for engineering medical data collection, storage and analysis. These tools enable : (a) automation of the collection of heterogeneous medical data from virtually any type of source (like IoT, API, files, remote repositories or databases, propriatary equipments, etc.) and its mapping to fully-customisable data representations enriched with semantics (DMWay tool) (b) a scalable and persistent data storage (c) easy yet powerful data analysis (TSANO tool) How the service will be delivered? It depends on the customer's need Method reference: https://asset.cetic.be/en/dmway/ https://www.cetic.be/analyse-prescriptive-au-service-de-industrie40

Univerzita Komenskeho V Bratislave (UK BA)

The laboratory performs research and scientific activities in the research of autonomic nervous system regulation. It uses Finometer (FMS) and Nexfin (Edwards Lifesciences) devices, which are used for non-invasive beat-to-beat blood pressure monitoring using volume-clamp method, and MedGem (Microlife) for determination of basal metabolism. It uses ECG Cardiofax 9620M (Nihon Cohden) for monitoring the electrical activity of the heart, RespiTrace (NIMS) for non-invasive respiratory monitoring by impedance method using chest and abdominal belts, CardioScreen 2000 (Medis) for non-invasive monitoring of various parameters associated with pumping function of the heart (systolic volume, systolic time intervals, etc.). It uses VaSera VS-1500N (Fukuda Denshi) characterization of arterial stiffness, EndoPAT 2000 (Itamar Medical) - characterization of endothelial dysfunction, InBody J10 (Biospace) - analysis of body composition, ECG (BTL; Pola V8) - non-invasive continuous bio signals monitoring, Finometer (Finapres medical systems), blood pressure, Flex Comp Infinity, Thought Technology for measuring the electrodermal activity, respiration, peripheral temperature, Neuroptics PLR200, pupilometry, Eyetracking (Pupil Labs) for eye movements, InBody 120 - body composition analysis.

Karolinska Institutet (KI)

## Overview This service supports the development and validation of biomedical signal processing pipelines for healthcare applications. SMAILE at Karolinska Institutet provides guidance for processing a range of biosignals, including ECG, EEG, EMG, respiration, accelerometers, gyroscope, and electrical bioimpedance. The focus is on signal filtering, feature extraction, event detection, and pipeline validation, aligned with clinical research standards. ### We provide expertise in: • Biomedical signal filtering and preprocessing • Feature extraction and clinical event annotation • Signal Analysis and Modeling • Quality assurance and reproducibility ### How can the service help you? Many early-stage companies and research projects lack robust, validated signal pipelines. This service enables reproducible analysis, clinical readiness, and regulatory alignment for biosignal-driven products and studies. ### How will the service be delivered? Can be delivered virtually or in conjunction with lab access. Clients share sample datasets, objectives, and processing goals. Duration: 2–6 weeks based on complexity. ## Additional Information ### Provider Description SMAILE provides advanced support in biomedical signal analytics, with experience in wearable health monitoring, digital phenotyping, and clinical-grade biosignal systems. ### Technical Description Pipelines are constructed and validated using Python (SciPy, MNE, NeuroKit), MATLAB, or other signal tools. ### Service Customization Clients may request focused support for real-time processing, offline batch analysis, or integration with AI modules. Output formats, sampling rates, and noise tolerance are adjustable.

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - Clinical Researchers and Investigators: For gaining insights into the feasibility of proposed studies and enhancing study designs with practical clinical input. - Healthcare Institutions: To expand research capabilities by connecting with technical and clinical experts and facilities. - Research and Development Teams: For testing new technologies or methodologies in applicable clinical contexts, ensuring innovative solutions are viable and effective. **Key Features:** - Technical Feasibility Assessment: Organizes and conducts comprehensive technical feasibility studies to evaluate the practicality and potential of clinical research projects. - Connection to Clinical Personnel: Facilitates collaboration between researchers and clinical experts at University Clinic Erlangen, ensuring access to expertise and resources necessary for study success. - Access to Real-Life and Laboratory Test Environments: Provides opportunities to conduct studies within associated clinics, leveraging previous experience in cardiology, neurology, and biomechanics to ensure practical and applicable results. **Possible Applications:** - Project Feasibility Evaluation: Assists in determining the feasibility of clinical research projects, helping to identify potential challenges and solutions early in the development phase. - Research Collaboration: Enhances research outcomes through the integration of clinical expertise and real-world testing environments, ensuring studies are rooted in clinical reality. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Platform:** [DPM-Research](https://www.iis.fraunhofer.de/de/ff/sse/health/mobile-health-lab/managementsystem-klinische-studien.html): A customizable eCRF platform that streamlines data and patient management and documentation in clinical studies, aligned with international standards and data protection regulations. **Who Can Benefit:** - Clinical Researchers: For streamlined data management processes that support robust research methodologies and regulatory compliance. - Regulatory Compliance Specialists: To ensure that clinical studies adhere to required international and local regulations, minimizing risk and enhancing credibility. - Healthcare Organizations: To manage clinical data effectively, improving research outcomes and operational efficiencies. **Key Features:** - Customized Data Management Solution: Provides a tailored data management and documentation platform designed to support clinical research studies. - eCRF Platform: Offers an electronic Case Report Form (eCRF) system customized for collecting and managing clinical research data efficiently. - Compliance with Standards: Ensures all studies are conducted in compliance with ISO 14155 and GDPR (DS-GVO), guaranteeing high standards in clinical investigation and data protection. **Possible Applications:** - Clinical Studies: Supports the management of clinical trial and patient data, ensuring accuracy, integrity, and regulatory compliance throughout the research lifecycle. - Data Documentation: Facilitates comprehensive data collection and documentation, improving the reliability and reproducibility of clinical research findings. **Who we are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Hospices Civils De Lyon (HCL)

Formative evaluation of surgical robot prototype (under development) in order to improve usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including design improvement recommendations and potential new use-related risks to mitigate Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of AMR (Autonomous Mobile Robot) for logistics: - performance and acceptability in realistic environment with representative users This packaged service includes : - Room rental for testing - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of surgical robot prototype in order to assess : - performance in realistic settings (using phantoms) - technical integration within operating theatre (interoperability, space constraints, etc.) This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Politecnico Di Milano (POLIMI)

Generation of synthetic virtual cohorts leveraging statistical and data-driven methods and featuring realistic anatomies, flow fields, and boundary conditions. These virtual populations can serve multiple purposes, from in silico trials for testing new devices and procedures, to training large deep learning models for disease-specific tasks and discoveries. Method Description: The service provides synthetic datasets for AI algorithm development, AI algorithm testing and digital twin based simulations (fluidynamic/structural simulations, fluid structure interaction) Method reference: https://doi.org/10.1016/j.cmpb.2023.107468

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Corelab: Echocardiography expertise & proofreading, ECG, cardiology

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Human Imaging platform, imaging, multimodal; MRI 3T Magnetom Prisma Siemens, MRI Factice PST, fNIRS, EEG Brainproducts, compatible with MRI, fNIRS (near-infrared spectroscopy) NIRx, compatible with MRI, Dual/quacores blades for computing cluster (480 cores), Hybrid imaging systems (EEG/MRI, NIRS/MRI) for methods development, MRI acquisition methods development, neurofeedback protocols development, data treatment & analysis methods development; Keywords: platform, imaging, MRI 3T, fNIRS, EEG, multimodal, hybrid, neuroinformatics, neuroimaging, brain

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Video and EMG-based facial expression analysis and posture detection during interventions using the mobile application - Assessment and analysis of biosignal data (EMG, ECG, and RSP) during interventions using the mobile application

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Motion laboratory rental for prototype testing : usability/technical testing and evaluation of medical device [no patients included]. Examples: Study of an exoskeleton's movements ; analysis of "fine" surgical robots mouvements. Motion lab equipped with: - 8 infrared cameras, 2 high-resolution cameras, 2 plantar pressure sensors - Wireless pressure sensors and non-invasive electromyographic sensors (system Cometa) - GAITrite system (Spatio-temporal gait parameter analysis system) - Dedicated workstation and data-storage for daily-use analysis Keywords: motion; rental; technical testing; medical device evaluation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Within the motion analysis laboratory, this service can offer: 3D motion analysis system: - full body motion analysis - Gait analysis thanks to a full GAITrite system - definition of an anatomical model - motion sequence validation with an exoskeleton - movement tracking of robotics Data acquisition can be completed with data analysis service. Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. Examples: clinical study to validate an exoskeleton on patients ; to validate a rehabilitation device on patients, ... Keywords: motion; GAIT analysis; robotics; exoskeleton; medical device validation

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Non-human genome sequencing Sequencing of bacterial or viral whole genomes with the possibility of sequence analysis and strain typing. Sequencing of SARS-CoV-2 amplicons. Sequencing of metagenome samples (with PCR-free protocol). This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA& RNA sequencing (microbial genomes, metagenomics) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Open access to instrumentation Possibility to rent specialised laboratory equipments, and also to get your own equipment tested by our team of scientists and lab experts. Scientific writing support and reporting can also be offered if needed.

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - MedTech & AI Companies: For obtaining high-quality, ethically sourced clinical datasets to fuel algorithm development without navigating hospital bureaucracy. - Clinical Researchers: For systematic, regulation-compliant data collection with full documentation and audit trail. **Key Features:** - End-to-end management of ethical approval processes (ethics committee submission, informed consent design) - Prospective data collection within Universitätsklinikum Erlangen clinical departments - Expert clinical annotation and ground truth labeling by domain specialists - Full GDPR compliance with pseudonymization/anonymization pipelines - Structured data output compatible with downstream AI training and analysis workflows **Possible Applications:** - Wearable Sensor Studies (e.g. Cardiology): Prospective collection of continuous ECG, PPG, or blood pressure data from cardiac patients for digital biomarker development and remote monitoring algorithm training. - Motion & Gait Analysis (Biomechanics): Systematic acquisition of IMU, force plate, and motion capture data in clinical and sports lab settings for movement disorder assessment, rehabilitation tracking, or athletic performance evaluation. - Neurological Signal Acquisition: Collection of EEG, EMG, or tremor sensor data from neurological patient cohorts to support AI-based diagnostic or therapy monitoring tools. - Real-World Evidence Datasets: Longitudinal data collection from ambulatory patients in everyday settings, enabling the development of algorithms that generalize beyond controlled lab environments. - Athletic Performance & Injury Prevention: Structured data gathering during sports science testing protocols to build datasets for injury risk prediction, load monitoring, and return-to-play decision support. - Multi-Modal Clinical Datasets: Combined collection of sensor data, imaging, lab values, and patient-reported outcomes to enable holistic, multi-modal AI model development. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, the Brain Molecular Imaging Centre (BMIC), supports clinical and pre-clinical research studies involving PET experiments. For large animal preclinical studies: the GE Discovery MI 5 PET/CT is a whole-body PET system designed for increased field of view to enable exceptionally high sensitivity, allowing AI, deep learning image reconstruction. The PET system is mainly used in humans and larger animals such as pigs. The system specifications are Transaxial FOV: 70 cm, Axial FOV: 25 cm, Spatial resolution: ~5 mm. Radiopharmacy CF, we then provide full service in conducting PET experiments. In this service, we offer our highly trained staff comprising PET camera operators, medical physicists, research nurses and physicians, as well as specialised staff conducting experiments with animals. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/bmic

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), has two PET-CT systems for animal imaging (Mediso nanoScan PET-CT). They are equipped with single-mouse, single-rat, or double-mouse beds. Four mice can be run simultaneously with exceptional image quality. The PET modules (spatial resolution 0.8mm) and a CT module (min. voxel size: 10-34 µm). KERIC collaborates closely with the Radio Pharmacy Core Facility (RCF), which allows us to deliver freshly produced radioactive ligands within a minimum time frame. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://ki.se/en/research/pet

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC), we have a preclinical 9.4T Bruker USR 94/30 MRI combined with Mediso nanoScan PET-CT systems for small-animal imaging equipped with single-mouse, singe-rat, or double-mouse beds. The PET module has a spatial resolution of 0.8mm. The state-of-the-art 9.4T MRI is equipped with three gradient bore sizes to arrange an effective inner diameter of 20cm (large animals), 12cm (medium animals) or 6cm (small animals). Methods in anatomical imaging, fMRI, Ex vivo, Pharmacological MRI and Cardiac imaging (CINE). For the mouse brain, a 4-channel phased array cry-coil drastically increased signal-to-noise. KERIC collaborates closely with the Radio Pharmacy Core Facility (RCF), which allows us to deliver freshly produced radioactive ligands within a minimum time frame. In this service, we offer full support in project consultation, ethical permits, module technical support, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/keric

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Service Keywords:** Psychological Studies, Affective Sensing, Multimodal Data, Stress/Emotion Detection, Project Design, Clinical Study Design, Scientific-Technical Consulting, Data Evaluation, Data Acquisition, Technical Support, Performance Evaluation/Reporting **Equipment:** - Expo-Box: Provides a controlled environment specifically designed for psycho-physiological studies. - Video Monitoring System: Captures behavioral indicators and emotional expressions for comprehensive analysis. - BioPac System: Measures ECG, respiration, oximetry, EEG, EMG, and skin temperature for detailed physiological monitoring. - AntNeuro EEG: Offers high-resolution brain activity monitoring for in-depth neurological assessments. - Tobii Eye Tracker: Tracks eye movements to infer cognitive and emotional states. - SHORE Facial Expression Extraction: Analyzes facial expressions to determine emotional cues and responses. **Who Can Benefit:** - Psychologists and Behavioral Scientists: For conducting detailed studies on emotional and stress responses to enhance understanding of human behavior. - Neuroscientists: To explore the neurological underpinnings of emotions and stress-related disorders. - Healthcare Professionals: To develop and test interventions aimed at improving emotional regulation and stress management in patients. - Technical Innovators: To design and refine affective sensing technologies in various applications such as wearable devices and therapeutic tools. - Research Institutions: For collaborative projects that require cutting-edge technology and expert guidance in psycho-physiological research. **Key Features:** - Multimodal Emotion Analysis: Specializes in the comprehensive assessment of emotional states through various physiological and behavioral indicators, including affective sensing and stress evaluation. - Controlled Environment: Offers a controlled setting ideal for psycho-physiological studies, enabling precise measurement and analysis of emotional responses. - Advanced Monitoring: Utilizes state-of-the-art equipment for detailed bio-monitoring and emotional analysis to support psychological research and clinical applications. - Expert Support: Provides expert assistance in recording high-quality data, assessing the feasibility of studies, and conducting patient and subject research across diverse fields, including automotive, art, and video games. **Possible Applications:** - Psychological Studies: Facilitates research into emotional responses and stress management, supporting the development of new psychological theories and therapeutic approaches. - Clinical Research: Assists in the design and execution of clinical trials focused on the psycho-physiological aspects of emotional disorders. - Affective Sensing: Supports the development and validation of technologies aimed at detecting and interpreting emotions in real-time. **Who we are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Synchronized measurement and recording of radar and reference signals in the body

Univerzita Komenskeho V Bratislave (UK BA)

The laboratory provides detection of RNA expression in low, medium and high throughput screening methods, including real-time PCR or microarray (MA). In additon, it provides detection of miRNA expression in low, as well as in high throughput screening meethods, including real-time PCR (qPCR) or microarray (MA). The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing.

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - Clinical Researchers: For strengthening study designs and hypotheses with a comprehensive understanding of existing literature. - Medical Product Developers: To advance the development of innovative medical solutions by integrating scientific research insights. - Academics and Healthcare Professionals: For engaging in scholarly dissemination of research, raising the profile and recognition of their work. **Key Features:** - Systematic Literature Research: Conducts comprehensive, literature searches to establish the scientific foundation for clinical investigation plans, regulatory submissions, and product positioning. - Clinical Investigation Plan (CIP) Development: Authors complete, ISO 14155-compliant study plans including objectives, design, endpoints, visit schedules, and statistical considerations. - Data Management Planning: Develops detailed DMPs covering database design, data collection procedures, validation rules, coding dictionaries, and quality assurance workflows. - Biostatistical Analysis: Provides full statistical support from sample size calculation and analysis plan development through to confirmatory analysis, subgroup evaluations, and results interpretation. - Clinical Investigation Report (CIR): Produces comprehensive final study reports documenting methods, results, and conclusions in accordance with ISO 14155 and regulatory expectations. - Scientific Dissemination & Publication: Supports or leads the preparation of peer-reviewed manuscripts, conference abstracts, and strategic dissemination planning. - Product Development Guidance: Translates scientific evidence into actionable recommendations for medical product design, differentiation, and clinical positioning. **Possible Applications:** - MDR Clinical Evaluation Support: Conducting systematic literature reviews and writing clinical evaluation reports (CER) to fulfill MDR Annex XIV requirements for medical device certification. - Planning Investigator-Initiated Trials: Developing robust CIPs and DMPs for academic research groups conducting clinical studies on novel sensor technologies or digital health solutions. - Regulatory Submission Documentation: Producing the complete documentation package (CIP, SAP, DMP, CIR) required for notified body review or competent authority submissions. - Biostatistical Consulting for MedTech Startups: Providing sample size calculations, endpoint selection guidance, and analysis strategies for companies designing their first clinical study. - Multi-Center Study Coordination: Harmonizing documentation, data management, and statistical reporting across multiple investigational sites. - Scientific Visibility for Industry Partners: Transforming proprietary study results into high-impact publications, raising the scientific profile of commercial innovations. - Grant Proposal Support: Strengthening research funding applications with solid literature foundations, well-designed study concepts, and credible statistical frameworks. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

"From home to hospital", Simulated hospital. Rental of the Simulation rooms, audio and video recording. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting the research, analysis. User testing.

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

Rental of the Simulation rooms, audio and video recording. Cameras, projectors for 4 sides; Acciden site simulation. "From home to hospital" Simulated hospital. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting research, analysis. User testing.

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC) offers simulated environmental operating rooms for surgical training and medical and robotic device testing. KERIC is a joint university- and hospital facility that gives you access to expert surgeons, medical doctors, technicians and researchers expertise. The four operation units are equipped with: • Anaesthesia equipment (Dräger Primus Infinity) • Monitoring equipment (Datex / Philips MX800) • Operating table (TruSystem 7000) • Surgical diathermy (Valleylab, ForceTriad) • Surgical light (Maquet Volista) • Patient warming units (Mistral Air) • Surgical suction • Standard surgical instruments Our operating rooms are regularly used for surgical training in transplantation, neuro/stroke, pediatric surgery, specialist trauma expertise, otorhinolaryngology, gynaecology, and pediatric surgery. In this service, we offer full support in project consultation, ethical permits, module technical support, expert surgeons, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://ki.se/en/research/research-infrastructure-and-environments/core-facilities-for-research/keric/experimental-surgery

Fondation De Cooperation Scientifique (IHU STRASBOURG)

8 clinical Operating Rooms 5 simulated Operating Rooms (preclinical)

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

"From home to hospital", Simulated hospital. Rental of the Simulation rooms, audio and video recording. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting the research, analysis. User testing.

Hospices Civils De Lyon (HCL)

Rental of the surgical facility (130m²), including: - a simulated operating room, with audio-video recording of testing sessions - an observation room with audio-video controls - a meeting room for debriefing, focus group , etc. - a convivial space to welcome participants

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Full-scale sleep analysis and sleep staging using polysomnography - Assessment of sleep disorders and disturbances, like sleep apnoea, snoring, restless-leg/arm syndrome, etc. - Analysis of facial expressions during sleep - Contactless measurement of heart rate and respiration

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - Clinical Researchers and Study Designers: For leveraging AI capabilities to refine and finalize study protocols, enhancing their effectiveness and feasibility. - Medical Product Developers: To assess the clinical viability of new products and solutions, ensuring they meet necessary evaluation criteria before market introduction. - Research and Development Teams: For innovative project development utilizing cutting-edge AI technologies to optimize research outcomes. **Key Features:** - AI-Driven Protocol Parsing: Leverages artificial intelligence to automatically parse, structure, and analyze clinical study protocols, extracting key parameters and identifying inconsistencies or gaps. - Feasibility Assessment: Conducts detailed evaluations to determine the viability of clinical studies for medical products, ensuring alignment with research goals and regulatory standards. - Design Optimization Recommendations: Generates actionable suggestions for protocol refinement – from endpoint selection and visit schedules to sample size considerations and risk mitigation. - Regulatory Alignment Check: Automatically flags protocol elements that may conflict with applicable standards (ISO 14155, MDR, ICH-GCP) or require additional justification. - Expert-in-the-Loop Guidance: Combines AI-generated insights with human expert review from clinical and technical specialists to deliver validated, trustworthy recommendations. **Applications:** - Study Protocol Evaluation: Employs AI technologies to enhance the accuracy and efficiency of protocol assessments, identifying potential challenges or areas for improvement. - Clinical Feasibility Analysis: Provides critical insights into the practicality of proposed research projects, aiding in the decision-making process for medical product development. - AI-Enhanced Clinical Research: Supports the integration of AI tools to streamline clinical study planning and execution. **Who we are:** The **Fraunhofer IIS** has established the **"Center for Sensor Technology and Digital Medicine"** in cooperation with the University Hospital Erlangen and the University of Erlangen-Nuremberg to enhance healthcare efficiency through **sensors** and **digital solutions**. This center focuses on integrating **innovative medical technologies** like **patient-specific therapies**, **digital health applications**, **medical diagnostics** via **wearables**, and **robotic systems** for care. Located at the University Hospital Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Full body motion analysis using inertial motion capture, including posturography and pressure distribution - Video-based motion and facial expression analysis - Standardized and reliable gold standard stress induction - Collection of established biopsychological stress markers for further processing - Assessment and analysis of digital biomarkers during stress - Physiological measurements

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Stress test platform; sport, cardiovascular

Hospices Civils De Lyon (HCL)

Summative evaluation of finalized surgical robot prototype (design freeze) in order to validate usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including root causes analysis of errors, close calls and use difficulties observed Prices range is indicative and depends on testing protocol complexity and particpants number

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Service Keywords:** Expertise in Electrophysiological Signals, Cardiovascular Diseases, Multimodal Data Acquisition (ECG, EMG, EEG, EOG, EDA), Project Design, Clinical Study Design, Scientific-Technical Consulting, Data Evaluation, Data Acquisition, Technical Support, Performance Evaluation/Reporting **Equipment:** - Biosign HRV-Scanner Model II: Mobile blood pressure monitor for evaluating heart rate variability. - SomnoMedics Sleep Monitor: Measures EEG, ECG, BP, oximetry, IMU, and EMG for comprehensive sleep assessments. - Biopac System: Monitors ECG, respiration, oximetry, EEG, EMG, and skin temperature for detailed physiological recordings. - Wireless Biopac System: Offers the same capabilities in a mobile format for versatile monitoring. - Vinno G55: Provides advanced ultrasonic imaging for cardiac and vascular assessments. - Maphera: A multimodal, portable, wireless biomedical acquisition system for a variety of physiological data. - Custo Guard Holter with Custo Wing: Long-term ECG monitoring for in-depth cardiac analysis. **Who Can Benefit:** - Cardiologists: For conducting advanced diagnostic assessments and managing patient care through detailed cardiac and electrophysiological data. - Biomedical Researchers: To explore cardiovascular physiology and develop innovative treatments or technologies. - Healthcare Engineers: For designing and testing medical devices that integrate with cardiovascular monitoring technologies. - Clinicians and Healthcare Institutions: To enhance clinical services and research capabilities with comprehensive cardiac assessment tools. **Key Features:** - Comprehensive Cardiac Monitoring: Equipped with advanced systems to evaluate a wide range of cardiovascular and electrophysiological parameters, ensuring precise and detailed analysis. - State-of-the-Art Technology: Utilizes cutting-edge equipment for both mobile and in-lab assessments, supporting diverse clinical and research applications. - Expert Support: Offers extensive scientific and technical consulting, with expertise in electrophysiological signals, to guide project design and enhance study outcomes through high-quality data recording and analysis. **Possible Applications:** - Clinical Trials: Facilitates rigorous evaluation of new cardiac therapies and devices, providing essential data for regulatory submission and clinical validation. - Patient Monitoring: Enables continuous monitoring of cardiac health, improving early detection and intervention for arrhythmias and other cardiovascular conditions. - Research and Development: Supports the development of novel diagnostic and therapeutic solutions by providing a robust platform for electrophysiological data acquisition. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Equipment:** - Gym Setup: Comprehensive facilities equipped for diverse sports and exercise testing. - Ergometer and Track: Standard equipment for controlled cardiovascular and endurance assessments. - BioPac System: Monitors ECG, respiration, oximetry, EEG, EMG, and skin temperature for thorough physiological analysis. - Wireless BioPac System: Offers mobile monitoring capabilities, ideal for field and in-lab scenarios. - Mobile ECG (Holter): Includes BTL Flexi 12, BTL Holter 08, and CardioSecure for continuous heart monitoring. - Smart Textiles: Integrates ECG and respiration monitoring directly into sportswear for seamless data collection. - XSens Cameras and Systems: Advanced biomechanical sensing with MVN Link, MVN Awinda 2, and pressure mapping for comprehensive motion capture and analysis. **Who Can Benefit:** - Sports Scientists and Researchers: For conducting advanced studies on human movement and optimizing athletic performance. - Athletic Trainers and Coaches: To design and refine training strategies based on precise biomechanical and physiological data. - Physical Therapists: To develop tailored rehabilitation programs and track recovery using comprehensive performance assessments. - Biomechanical Engineers: For developing sports-related technologies and equipment by leveraging biomechanical insights. - Professional and Amateur Athletes: To enhance performance and reduce the risk of injuries through data-driven insights. **Key Features:** - Multimodal Physical Activity Analysis: Specializes in comprehensive assessments of athletic performance using a wide range of physiological and biomechanical measurements. - State-of-the-Art Equipment: Provides versatile setups and advanced monitoring technologies to capture detailed data on physical activity and sports performance. - Expert Support: Offers robust scientific and technical consulting, featuring expertise in both electrophysiological signals and biomechanics, to optimize study design and data analysis. **Possible Applications:** - Athletic Performance Testing: Facilitates detailed analysis of athletes' physical abilities and limitations, supporting personalized training and rehabilitation programs. - Sports Science Research: Enables the study of biomechanics and physiology in sports settings, contributing to the development of innovative training methods and performance-enhancing techniques. - Injury Prevention and Rehabilitation: Assists in identifying risk factors and monitoring recovery progress, helping to minimize injury occurrence and expedite rehabilitation. - Neurological Disease Assessment: Identifying the severity of a Parkinsons disease from the gait of the patient. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Transcriptome sequencing (RNA-seq) Sequencing of mRNA (poly A based method) followed by fusion detection or germline analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o RNA sequencing (total RNA, mRNA) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Centre Hospitalier Universitaire De Grenoble (CHUGA)

Formative evaluation of medical devices: user testing of any medical device prototype in order to improve usability (according to IEC 62366-1). It includes: - writing protocols depending user profiles. - recruitment of required healthcare professionals and patients - rental of the operating room if needed - rental of phantoms - one or several iterative user testing steps and result analyses - evaluation report including ergonomic corrections and guidelines to bring to the medical device

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Whole genome or targeted DNA sequencing Sequencing of the entire human genome (with a PCR-free protocol) or selected parts of the genome (through exome or panel sequencing), followed by germline or somatic analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA sequencing (Whole Genome Seq (WGS), Whole Exome Seq (WES), Panels) o Bioinformatics (Bioinformatic analysis (data generated at CG) Equipment: Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio) Prospective Use case: AI based software solution uses WGS data to identify genetic biomarkers to help clinicians either during diagnostic phase and/or at the treatment phase in order to identify genetic aberrations possibly explaining the disease onset or to assist in the therapeutic decisions such as for example in breast cancer the presence of BRCA1 mutation. AI software can be trained to learn to deliver diagnostic based on WGS data (especially needed in the field of rare diseases) to recognize genetic variations (from single nucleotide to over 50bp deletion or insertion) in a more robust and accurate manner (to limit generation of false negative or false positive cases) to support clinicians in their decision process.