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3T MRI Imaging data acquisition (Clinical)
Karolinska Institutet (KI)
Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques.
The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. We offer a state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support.
For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc
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7T MRI Imaging data acquisition (Clinical)
Karolinska Institutet (KI)
Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques.
The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. A unique next-generation clinical 7 Tesla Siemens MAGNETOM Terra.X. equipped with an ultra-high field scanner also offers cutting-edge gradient performance (130 mT/m at 250 T/m/s), parallel transmission, as well as deep learning-based acceleration and denoising for improved image quality. Micrometre resolution in vivo for microstructural imaging and layered fMRI. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support.
For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc
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Access to Compound Collection
Karolinska Institutet (KI)
The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/)
The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science.
Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology.
Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis).
The service: Access to compound collection
https://www.cbcs.se/the-compound-collection
The Scilifelab Compound Collection is managed by the Compound Center at CBCS KI, and is based on donations of high-quality sets from the pharmaceutical industry (Biovitrum, Karobio, Orexo/Biolipox, KDev) and has been developed and expanded with compounds from various commercial compound vendors.
The compounds can be readily available in assay-ready plates through acoustic nano-litre scale liquid dispensing or in 96-tube racks; compounds are stored at 10mM concentration in DMSO solution at - 20 °C under humidity control.
We provide:
o Management, storage, and processing of solids and liquids.
o Compound delivery and interface with key customers.
o Performance of instruments and automation that support these operations.
o Analytical techniques used for quality assurance.
o Sample informatics, including registration and compound quality data.
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Assay development & highthroughput screening
Karolinska Institutet (KI)
The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/)
The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science.
Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology.
Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis).
The service: Assay development & highthroughput screening
We provide expertise and technical support in the following areas:
o Access to small-molecule compound libraries and robotic instrumentation.
o Expertise in assay development and automation.
o High-throughput screening: biochemical target-based, cell-based and phenotypic.
o High-throughput imaging technology.
o Computational chemistry and modelling.
o Medicinal chemistry expertise.
o Chemical Biology Platform.
Perspective use case:
Purpose
The Cell Painting technology can be used to visualize many cellular parameters simultaneously, using organelle-specific fluorescent dyes and high-content imaging. This approach allows you to systematically visualize how cell morphologies react to certain stimuli, like chemical perturbations. It is thus possible to foresee in the near future that the CP technology is a valuable technology to create large systematic AI minable cell morphology resources and customized validation data sets for profiling small molecules and other treatment modalities. Development of new AI software for morphology profiling, cell segmentation for validation sets for functional perturbation assays are needed for future precision medicine.
Description of service/ technology:
Cell painting, high-content imaging, high-throughput screening
Drug library design and delivery, cell culture and immunofluorescence staining
Dataset generation, data analysis
AI software development
Expected outcome:
New dataset generation to train AI algorithm on the different type of images generated.
Improvement of AI algorithm.
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Backend development platforms - Data & AI OPS
Centre D'Excellence En Technologies De L'Information Et De La Communication (CETIC)
The collection of data from various sources (devices, files, interconnected services, etc.) is a complex step and typically falls outside the core business of medical sector companies, which aim to focus on the analysis of this data.
How can the service help you?
The CETIC provides access to a highly customizable catalog of tools for engineering medical data collection, storage and analysis. These tools enable :
(a) automation of the collection of heterogeneous medical data from virtually any type of source (like IoT, API, files, remote repositories or databases, propriatary equipments, etc.) and its mapping to fully-customisable data representations enriched with semantics (DMWay tool)
(b) a scalable and persistent data storage
(c) easy yet powerful data analysis (TSANO tool)
How the service will be delivered?
It depends on the customer's need
Method reference:
https://asset.cetic.be/en/dmway/
https://www.cetic.be/analyse-prescriptive-au-service-de-industrie40
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Biobanking: Human biological samples; preparation, aliquoting, storage, extraction, fresh, frozen
Centre Hospitalier Universitaire De Rennes (CHU RENNES)
Kit preparation; reception of sample +/- inventry +/-relabelling +/- entry of additional medical data +/- managing of consents; aliquoting; ficoll; cell count viability; extraction (RNA, DNA); freezing and conservation (-150°C, -80°C, -20°C, +4°C, nitrogen); cell culture and maintenance; preparation of parafin from fresh or frozen tissues; biobank, biological sample, aliquot, storage, tissue, cell, blood, urine
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