Neurology services

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. We offer a state-of-the-art 3 Tesla GE SIGNA Premier system-wide bore gantry and high-performance XT gradients. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, MRI Centre, aims to catalyse novel and translational research using MRI. A unique next-generation clinical 7 Tesla Siemens MAGNETOM Terra.X. equipped with an ultra-high field scanner also offers cutting-edge gradient performance (130 mT/m at 250 T/m/s), parallel transmission, as well as deep learning-based acceleration and denoising for improved image quality. Micrometre resolution in vivo for microstructural imaging and layered fMRI. We support all types of MRI studies in humans, ranging from small single-centre projects to large-scale international multi-centre studies. A special focus is on offering MRI suitable for multi-modal integration such as CT, PET, EEG and MEG. The KI MRI Centre also offers a full-service lab for drawing blood and investigating psychophysiology (EDA, PPG, Eye-tracking) along with standardised image post-processing and data storage facilities with cluster computing for data analysis. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://imagingresearch.se/facilities/corefacilities/mrc

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Access to compound collection https://www.cbcs.se/the-compound-collection The Scilifelab Compound Collection is managed by the Compound Center at CBCS KI, and is based on donations of high-quality sets from the pharmaceutical industry (Biovitrum, Karobio, Orexo/Biolipox, KDev) and has been developed and expanded with compounds from various commercial compound vendors. The compounds can be readily available in assay-ready plates through acoustic nano-litre scale liquid dispensing or in 96-tube racks; compounds are stored at 10mM concentration in DMSO solution at - 20 °C under humidity control. We provide: o Management, storage, and processing of solids and liquids. o Compound delivery and interface with key customers. o Performance of instruments and automation that support these operations. o Analytical techniques used for quality assurance. o Sample informatics, including registration and compound quality data.

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Assay development & highthroughput screening We provide expertise and technical support in the following areas: o Access to small-molecule compound libraries and robotic instrumentation. o Expertise in assay development and automation. o High-throughput screening: biochemical target-based, cell-based and phenotypic. o High-throughput imaging technology. o Computational chemistry and modelling. o Medicinal chemistry expertise. o Chemical Biology Platform. Perspective use case: Purpose The Cell Painting technology can be used to visualize many cellular parameters simultaneously, using organelle-specific fluorescent dyes and high-content imaging. This approach allows you to systematically visualize how cell morphologies react to certain stimuli, like chemical perturbations. It is thus possible to foresee in the near future that the CP technology is a valuable technology to create large systematic AI minable cell morphology resources and customized validation data sets for profiling small molecules and other treatment modalities. Development of new AI software for morphology profiling, cell segmentation for validation sets for functional perturbation assays are needed for future precision medicine. Description of service/ technology: Cell painting, high-content imaging, high-throughput screening Drug library design and delivery, cell culture and immunofluorescence staining Dataset generation, data analysis AI software development Expected outcome: New dataset generation to train AI algorithm on the different type of images generated. Improvement of AI algorithm.

Centre D'Excellence En Technologies De L'Information Et De La Communication (CETIC)

The collection of data from various sources (devices, files, interconnected services, etc.) is a complex step and typically falls outside the core business of medical sector companies, which aim to focus on the analysis of this data. How can the service help you? The CETIC provides access to a highly customizable catalog of tools for engineering medical data collection, storage and analysis. These tools enable : (a) automation of the collection of heterogeneous medical data from virtually any type of source (like IoT, API, files, remote repositories or databases, propriatary equipments, etc.) and its mapping to fully-customisable data representations enriched with semantics (DMWay tool) (b) a scalable and persistent data storage (c) easy yet powerful data analysis (TSANO tool) How the service will be delivered? It depends on the customer's need Method reference: https://asset.cetic.be/en/dmway/ https://www.cetic.be/analyse-prescriptive-au-service-de-industrie40

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Kit preparation; reception of sample +/- inventry +/-relabelling +/- entry of additional medical data +/- managing of consents; aliquoting; ficoll; cell count viability; extraction (RNA, DNA); freezing and conservation (-150°C, -80°C, -20°C, +4°C, nitrogen); cell culture and maintenance; preparation of parafin from fresh or frozen tissues; biobank, biological sample, aliquot, storage, tissue, cell, blood, urine

Univerzita Komenskeho V Bratislave (UK BA)

The laboratory performs research and scientific activities in the research of autonomic nervous system regulation. It uses Finometer (FMS) and Nexfin (Edwards Lifesciences) devices, which are used for non-invasive beat-to-beat blood pressure monitoring using volume-clamp method, and MedGem (Microlife) for determination of basal metabolism. It uses ECG Cardiofax 9620M (Nihon Cohden) for monitoring the electrical activity of the heart, RespiTrace (NIMS) for non-invasive respiratory monitoring by impedance method using chest and abdominal belts, CardioScreen 2000 (Medis) for non-invasive monitoring of various parameters associated with pumping function of the heart (systolic volume, systolic time intervals, etc.). It uses VaSera VS-1500N (Fukuda Denshi) characterization of arterial stiffness, EndoPAT 2000 (Itamar Medical) - characterization of endothelial dysfunction, InBody J10 (Biospace) - analysis of body composition, ECG (BTL; Pola V8) - non-invasive continuous bio signals monitoring, Finometer (Finapres medical systems), blood pressure, Flex Comp Infinity, Thought Technology for measuring the electrodermal activity, respiration, peripheral temperature, Neuroptics PLR200, pupilometry, Eyetracking (Pupil Labs) for eye movements, InBody 120 - body composition analysis.

Karolinska Institutet (KI)

## Overview This service supports the development and validation of biomedical signal processing pipelines for healthcare applications. SMAILE at Karolinska Institutet provides guidance for processing a range of biosignals, including ECG, EEG, EMG, respiration, accelerometers, gyroscope, and electrical bioimpedance. The focus is on signal filtering, feature extraction, event detection, and pipeline validation, aligned with clinical research standards. ### We provide expertise in: • Biomedical signal filtering and preprocessing • Feature extraction and clinical event annotation • Signal Analysis and Modeling • Quality assurance and reproducibility ### How can the service help you? Many early-stage companies and research projects lack robust, validated signal pipelines. This service enables reproducible analysis, clinical readiness, and regulatory alignment for biosignal-driven products and studies. ### How will the service be delivered? Can be delivered virtually or in conjunction with lab access. Clients share sample datasets, objectives, and processing goals. Duration: 2–6 weeks based on complexity. ## Additional Information ### Provider Description SMAILE provides advanced support in biomedical signal analytics, with experience in wearable health monitoring, digital phenotyping, and clinical-grade biosignal systems. ### Technical Description Pipelines are constructed and validated using Python (SciPy, MNE, NeuroKit), MATLAB, or other signal tools. ### Service Customization Clients may request focused support for real-time processing, offline batch analysis, or integration with AI modules. Output formats, sampling rates, and noise tolerance are adjustable.

Universita Degli Studi Di Pavia (UNIPV)

This service offers the construction and simulation of brain digital twins for neurological and neuropharmacological applications. The simulations are typically applicable to single subject data for developing personalized medicine and pharma. Method description: Raw structural and functional data is preprocessed and analyzed to create brain connectivity data. The computational framework is tuned against experimental data to simulate brain dynamics and optimize physiological parameters, e.g., excitatory and inhibitory activity. In order to obtain personalized digital brain twin single-subject data must be used. Method reference: Local method respecting General Data Protection Regulation (GDPR)

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - Clinical Researchers and Investigators: For gaining insights into the feasibility of proposed studies and enhancing study designs with practical clinical input. - Healthcare Institutions: To expand research capabilities by connecting with technical and clinical experts and facilities. - Research and Development Teams: For testing new technologies or methodologies in applicable clinical contexts, ensuring innovative solutions are viable and effective. **Key Features:** - Technical Feasibility Assessment: Organizes and conducts comprehensive technical feasibility studies to evaluate the practicality and potential of clinical research projects. - Connection to Clinical Personnel: Facilitates collaboration between researchers and clinical experts at University Clinic Erlangen, ensuring access to expertise and resources necessary for study success. - Access to Real-Life and Laboratory Test Environments: Provides opportunities to conduct studies within associated clinics, leveraging previous experience in cardiology, neurology, and biomechanics to ensure practical and applicable results. **Possible Applications:** - Project Feasibility Evaluation: Assists in determining the feasibility of clinical research projects, helping to identify potential challenges and solutions early in the development phase. - Research Collaboration: Enhances research outcomes through the integration of clinical expertise and real-world testing environments, ensuring studies are rooted in clinical reality. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Hospices Civils De Lyon (HCL)

Formative evaluation of surgical robot prototype (under development) in order to improve usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including design improvement recommendations and potential new use-related risks to mitigate Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of AMR (Autonomous Mobile Robot) for logistics: - performance and acceptability in realistic environment with representative users This packaged service includes : - Room rental for testing - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Hospices Civils De Lyon (HCL)

Technical testing of surgical robot prototype in order to assess : - performance in realistic settings (using phantoms) - technical integration within operating theatre (interoperability, space constraints, etc.) This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital if required - Protocol elaboration - Testing phase - Evaluation report, including recommendations if applicable Prices range is indicative and depends on testing protocol complexity and particpants number

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Full body motion analysis on a treadmill - Gait analysis with real-time feedback in virtual reality environments

Centre Hospitalier Universitaire De Rennes (CHU RENNES)

Human Imaging platform, imaging, multimodal; MRI 3T Magnetom Prisma Siemens, MRI Factice PST, fNIRS, EEG Brainproducts, compatible with MRI, fNIRS (near-infrared spectroscopy) NIRx, compatible with MRI, Dual/quacores blades for computing cluster (480 cores), Hybrid imaging systems (EEG/MRI, NIRS/MRI) for methods development, MRI acquisition methods development, neurofeedback protocols development, data treatment & analysis methods development; Keywords: platform, imaging, MRI 3T, fNIRS, EEG, multimodal, hybrid, neuroinformatics, neuroimaging, brain

Univerzita Komenskeho V Bratislave (UK BA)

Cell microscopy - Confocal laser scanning microscop Zeiss LSM 880 (Fluorescence microscopy, Real-time recording, Time-resolved microscopy, Whole tissue scanning, Image processing)

Univerzita Komenskeho V Bratislave (UK BA)

Small animal MRI imaging: Bruker BioSpec 70/20 USR 7 T preclinical (MRI, MRS, MRSI, relaxometry, iron quantification, Image processing and analysis)

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Neuro Imaging platform includes: -MEG/EEG (Elekta Neuromag) : 204 gradiometers, 102 magnetometers, 128 EEG channels. - MRI/MEG-compatible EEG amplifier (Brain Products) : 64 channels. - MRI 1.5T (Siemens Espree) - Audio, visual and sensitive stimulation equipment - Dedicated HPC workstation for real-time signal processing The service offers to conduct a clinical study with MEG/EEG/MRI Imaging to generate new brain-related data: - Data acquisition & analysis +/- technical expertise. - Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. - Example: provide new clinical data to assess/validate the performance/robustness of an AI system in a specific intended use Keywords: Neuro Imaging; MRI; MEG; imaging data acquisition

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Video and EMG-based facial expression analysis and posture detection during interventions using the mobile application - Assessment and analysis of biosignal data (EMG, ECG, and RSP) during interventions using the mobile application

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Motion laboratory rental for prototype testing : usability/technical testing and evaluation of medical device [no patients included]. Examples: Study of an exoskeleton's movements ; analysis of "fine" surgical robots mouvements. Motion lab equipped with: - 8 infrared cameras, 2 high-resolution cameras, 2 plantar pressure sensors - Wireless pressure sensors and non-invasive electromyographic sensors (system Cometa) - GAITrite system (Spatio-temporal gait parameter analysis system) - Dedicated workstation and data-storage for daily-use analysis Keywords: motion; rental; technical testing; medical device evaluation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Within the motion analysis laboratory, this service can offer: 3D motion analysis system: - full body motion analysis - Gait analysis thanks to a full GAITrite system - definition of an anatomical model - motion sequence validation with an exoskeleton - movement tracking of robotics Data acquisition can be completed with data analysis service. Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. Examples: clinical study to validate an exoskeleton on patients ; to validate a rehabilitation device on patients, ... Keywords: motion; GAIT analysis; robotics; exoskeleton; medical device validation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Neuro Imaging platform includes: -MEG/EEG (Elekta Neuromag) : 204 gradiometers, 102 magnetometers, 128 EEG channels. - MRI/MEG-compatible EEG amplifier (Brain Products) : 64 channels. - MRI 1.5T (Siemens Espree) - Audio, visual and sensitive stimulation equipment - Dedicated HPC workstation for real-time signal processing The service offers to conduct a clinical study with MEG/EEG/MRI Imaging to generate new brain-related data: - Data acquisition & analysis +/- technical expertise. - Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. - Example: provide new clinical data to assess/validate the performance/robustness of an AI system in a specific intended use Keywords: Neuro Imaging; MRI; MEG; imaging data acquisition

Universita Degli Studi Di Pavia (UNIPV)

This service offers the construction and simulation of neurons and micro-circuits for neurological and neuropharmacological applications. The models can be combined to develop and simulate brain digital twins of neuropathologies. Method description: Customization of micro-circuits tailored to specific pathological and/or pharmacological needs. These circuits will be refined and optimized for simulations, with the resulting data integrated into a clinical framework and/or used to model pathological behaviors in a virtual brain twin. Method reference: Local method respecting General Data Protection Regulation (GDPR).

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Service Keywords:** Expertise in Human Movement, Neurological Diseases, Project Design, Clinical Study Design, Scietific-Technical Constulting, Data Evaluation, Data Acquisition, Technical Support, Performance Evaluation/Reporting, **Equipment:** - 10x Vero Cameras (infrared) - 2x VUe Cameras (visible) - 2x AMTI Optima Pressure Plates - Cometa Wave Plus (EMG): 12x MiniWasve EMG Sensors, PICO EMG Sensors - 2x Blue Trident IMU (low and high g Accelerometer, Gyroscope, Magnetometer) **Who Can Benefit:** - Data Scientists and AI Researchers: To obtain high-quality datasets for training and validating AI models that can identify and predict gait abnormalities and differentiate between various movement disorders. For designing, implementing, and testing algorithms that automate the analysis of gait patterns, thereby improving efficiency and accuracy. - Healthcare Technology Innovators: To integrate AI-driven insights into wearable devices or diagnostic tools that enhance patient monitoring and care delivery. - Clinical Researchers: To explore AI applications in clinical trials, enhancing understanding of treatment impacts on gait and mobility in various disorders. - Software Developers: For creating user-friendly AI software interfaces that clinicians can use to easily interpret results and apply AI insights to patient care. - Rehabilitation Professionals: To utilize AI-enhanced feedback for developing adaptive rehabilitation protocols that respond to instrumented changes in gait patterns. - Biomedical Engineers: For advancing AI-driven biomechanical analysis tools that can be used in designing prosthetics, orthotics, and assistive devices. **Key Features:** - User-Friendly Interface: Intuitive software interface for both technical and non-technical users, ensuring ease of use for engineers, clinicians, and other healthcare personnel. - Comprehensive Reporting: Provides detailed reports and visualizations of gait characteristics, such as stride length, speed, and variability, to quantify gait patterns and draw clinically relevant conclusions. - Experienced Personnel: Gain access to a team of specialists with extensive experience in analyzing gait and movement patternsassociated with neurological conditions. Our experts possess in-depth knowledge and skills to provide accurate assessments and valuable insights, supporting the development of your application in the field of neurological disorders. - Directly Attached to Clinic: Patients and physicians can easily access the state of the art facility for gait and movement analysis. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Univerzita Komenskeho V Bratislave (UK BA)

Full-service metabolomics analysis in-vitro and ex-vivo using NMR spectroscopy. Proficiency in instrumentation performance, metabolomic measurement protocols and data analysis for clinical, academic and indystry applications.

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Non-human genome sequencing Sequencing of bacterial or viral whole genomes with the possibility of sequence analysis and strain typing. Sequencing of SARS-CoV-2 amplicons. Sequencing of metagenome samples (with PCR-free protocol). This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA& RNA sequencing (microbial genomes, metagenomics) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Karolinska Institutet (KI)

The Unit: Chemical Biology Consortium Sweden (https://www.scilifelab.se/units/cbcs/) The infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Chemical Biology Consortium Sweden (CBCS) is a national research infrastructure offering an extensive portfolio of services - from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools (small organic molecules) for applications within life science research in general and with the ultimate goal to explore complex biology. Our units comprise compound handling labs (hosting the SciLifeLab Compound Collection of ca 350,000 molecules), screening labs (microtiter format liquid handling robotics and a wide range of plate readers), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis). The service: Open access to instrumentation Possibility to rent specialised laboratory equipments, and also to get your own equipment tested by our team of scientists and lab experts. Scientific writing support and reporting can also be offered if needed.

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Conduct an interventional clinical study within clinical research facility CEA-Clinatec : Operating room and hospitalisation room, with access to Grenoble-Alpes University Hospital's network of clinicians. Clinical and regulatory support to set up and submit the clinical study within French regulatory framework. Operating room equipped with: - Neuro navigation robotic system ROSA - Intraoperative 1,5T MRI (Espree, Siemens): positioned on a rail to go into the operating room during surgery - Mobile X-ray unit (general Electric) - Stereotaxis interventional radiography chain (Apelem) Keywords: operating room; clinical study; surgery; neurology; medical device validation

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

Facility rental for: - protoype testing: usability/technical testing and evaluation of medical device [no patients included] - MRI compatibility evaluation of medical devices Rental of the operating room including: - surgical and anesthesic equipment MRI-compatible - anesthesic area - hospitalisation rooms if needed OR equipped with: - Neuro navigation robotic system ROSA - Intraoperative 1,5T MRI (Espree, Siemens): positioned on a rail to go into the operating room during surgery - Mobile X-ray unit (general Electric) - Stereotaxis interventional radiography chain (Apelem) Keywords: operating room; medical device evaluation

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional and unique collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility, neuronal brain activity using magnetoencephalography (NatMEG). NatMEG is Sweden's first and only research laboratory for whole-head measurements of neuronal brain activity using MEG. The state-of-the-art On-scalp MEG promises improved sensitivity and spatial precision compared to traditional cryogenic MEG. The system uses 128 novel optically pumped magnetometer (OPM) sensors and will be the first of its kind in the world. It includes 32 digital trigger channels, 8 bipolar analogue input and 8 bipolar output channels that are recorded along with the MEG data with integrated 128-channel EEG for simultaneous measurement. Due to the flexibility of OPMs, the sensors can also be used to record other electrophysiological signals, such as magnetocardiography (MCG), magnetomyography (MMG) and magnetoretinography (MRG). All MEG recordings are done inside a Vacuumschmelze GmbH Ak3B magnetically shielded room (MSR) with 2 high-permeability layers. The inside dimensions of the MSR are approximately 3m x 4m x 2.5m. In this service, we offer full support in project consultation, ethical permits and module technical support. For more information, visit the website: https://www.natmeg.se/

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Who Can Benefit:** - MedTech & AI Companies: For obtaining high-quality, ethically sourced clinical datasets to fuel algorithm development without navigating hospital bureaucracy. - Clinical Researchers: For systematic, regulation-compliant data collection with full documentation and audit trail. **Key Features:** - End-to-end management of ethical approval processes (ethics committee submission, informed consent design) - Prospective data collection within Universitätsklinikum Erlangen clinical departments - Expert clinical annotation and ground truth labeling by domain specialists - Full GDPR compliance with pseudonymization/anonymization pipelines - Structured data output compatible with downstream AI training and analysis workflows **Possible Applications:** - Wearable Sensor Studies (e.g. Cardiology): Prospective collection of continuous ECG, PPG, or blood pressure data from cardiac patients for digital biomarker development and remote monitoring algorithm training. - Motion & Gait Analysis (Biomechanics): Systematic acquisition of IMU, force plate, and motion capture data in clinical and sports lab settings for movement disorder assessment, rehabilitation tracking, or athletic performance evaluation. - Neurological Signal Acquisition: Collection of EEG, EMG, or tremor sensor data from neurological patient cohorts to support AI-based diagnostic or therapy monitoring tools. - Real-World Evidence Datasets: Longitudinal data collection from ambulatory patients in everyday settings, enabling the development of algorithms that generalize beyond controlled lab environments. - Athletic Performance & Injury Prevention: Structured data gathering during sports science testing protocols to build datasets for injury risk prediction, load monitoring, and return-to-play decision support. - Multi-Modal Clinical Datasets: Combined collection of sensor data, imaging, lab values, and patient-reported outcomes to enable holistic, multi-modal AI model development. **Who We Are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Karolinska Institutet (KI)

The Swedish node is a collaboration between Karolinska Institutet, SciLifeLab and RISE. Together, we offer world-leading services with our unique collection of core facilities. We can grant services in expert consulting, virtual- and physical testing in the range of in vivo imaging, ex vivo OMICS, pharmaceutical development, simulated healthcare environments, AI-system validation and development, advanced data analysis and other data-driven life science. Prospective data set collection: A full-service collection of new data sets. This service serves to create data sets on-demand according to the needs and requirements of the SME for TEF-project purposes, such as validation. Data sets will primarily comprise in vivo imaging data (PET, CT, MRI, MEG, EEG), ex vivo imaging, and OMICS data within neuro and cancer. Data can be generated by CIR and SciLifeLab infrastructures within our “Physical Testing” services or assembled from publicly available databases and research collaborations. We provide expertise and technical support in the following areas: o Project design& management o Ethical application support o Data collection o Data assembly o Data cleaning, annotation, anonymisation This service can typically directly collaborate with “physical testing services” and technology infrastructures to generate raw data material.

Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev (Fraunhofer)

**Service Keywords:** Psychological Studies, Affective Sensing, Multimodal Data, Stress/Emotion Detection, Project Design, Clinical Study Design, Scientific-Technical Consulting, Data Evaluation, Data Acquisition, Technical Support, Performance Evaluation/Reporting **Equipment:** - Expo-Box: Provides a controlled environment specifically designed for psycho-physiological studies. - Video Monitoring System: Captures behavioral indicators and emotional expressions for comprehensive analysis. - BioPac System: Measures ECG, respiration, oximetry, EEG, EMG, and skin temperature for detailed physiological monitoring. - AntNeuro EEG: Offers high-resolution brain activity monitoring for in-depth neurological assessments. - Tobii Eye Tracker: Tracks eye movements to infer cognitive and emotional states. - SHORE Facial Expression Extraction: Analyzes facial expressions to determine emotional cues and responses. **Who Can Benefit:** - Psychologists and Behavioral Scientists: For conducting detailed studies on emotional and stress responses to enhance understanding of human behavior. - Neuroscientists: To explore the neurological underpinnings of emotions and stress-related disorders. - Healthcare Professionals: To develop and test interventions aimed at improving emotional regulation and stress management in patients. - Technical Innovators: To design and refine affective sensing technologies in various applications such as wearable devices and therapeutic tools. - Research Institutions: For collaborative projects that require cutting-edge technology and expert guidance in psycho-physiological research. **Key Features:** - Multimodal Emotion Analysis: Specializes in the comprehensive assessment of emotional states through various physiological and behavioral indicators, including affective sensing and stress evaluation. - Controlled Environment: Offers a controlled setting ideal for psycho-physiological studies, enabling precise measurement and analysis of emotional responses. - Advanced Monitoring: Utilizes state-of-the-art equipment for detailed bio-monitoring and emotional analysis to support psychological research and clinical applications. - Expert Support: Provides expert assistance in recording high-quality data, assessing the feasibility of studies, and conducting patient and subject research across diverse fields, including automotive, art, and video games. **Possible Applications:** - Psychological Studies: Facilitates research into emotional responses and stress management, supporting the development of new psychological theories and therapeutic approaches. - Clinical Research: Assists in the design and execution of clinical trials focused on the psycho-physiological aspects of emotional disorders. - Affective Sensing: Supports the development and validation of technologies aimed at detecting and interpreting emotions in real-time. **Who we are:** The **Fraunhofer Insitute for Integrated Circuits (Fraunhofer IIS)** has established the **"Center for Sensor Technology and Digital Medicine" (CEMDIS)** in cooperation with the Universitätsklinikum Erlangen and the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) to enhance modern healthcare through **innovative sensor technology** and **digital solutions**. This center focuses on integrating **innovative medical technologies** such as **wearables** and **robotic systems** to support **medical diagnostics**, **patient monitoring** and **evaluating patient-specific therapies** by providing digital health solutions für real-life healthcare. Located at the Universitätsklinikum Erlangen, it offers unique infrastructures for the **development**, **integration**, and **validation** of novel health technologies, providing companies opportunities for **technological advancements**. For more information, visit the [Fraunhofer IIS website](https://www.iis.fraunhofer.de/de/ff/sse/health/zentrum-sensorik-medizin.html).

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Synchronized measurement and recording of radar and reference signals in the body

Univerzita Komenskeho V Bratislave (UK BA)

The laboratory provides detection of RNA expression in low, medium and high throughput screening methods, including real-time PCR or microarray (MA). In additon, it provides detection of miRNA expression in low, as well as in high throughput screening meethods, including real-time PCR (qPCR) or microarray (MA). The service includes insight into technology, sample preparation, and partial or full bioinformatic data processing.

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

"From home to hospital", Simulated hospital. Rental of the Simulation rooms, audio and video recording. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting the research, analysis. User testing.

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

Rental of the Simulation rooms, audio and video recording. Cameras, projectors for 4 sides; Acciden site simulation. "From home to hospital" Simulated hospital. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting research, analysis. User testing.

Karolinska Institutet (KI)

Centre for Imaging Research (CIR) is a world-leading imaging centre at Karolinska Institutet in Sweden in collaboration with SciLIfeLab and RISE. It offers an exceptional collection of core facilities for cutting-edge structural, functional, and metabolic in vivo multimodal imaging and endovascular/minimally invasive surgical techniques. The core facility Karolinska Experimental Research and Imaging Centre (KERIC) offers simulated environmental operating rooms for surgical training and medical and robotic device testing. KERIC is a joint university- and hospital facility that gives you access to expert surgeons, medical doctors, technicians and researchers expertise. The four operation units are equipped with: • Anaesthesia equipment (Dräger Primus Infinity) • Monitoring equipment (Datex / Philips MX800) • Operating table (TruSystem 7000) • Surgical diathermy (Valleylab, ForceTriad) • Surgical light (Maquet Volista) • Patient warming units (Mistral Air) • Surgical suction • Standard surgical instruments Our operating rooms are regularly used for surgical training in transplantation, neuro/stroke, pediatric surgery, specialist trauma expertise, otorhinolaryngology, gynaecology, and pediatric surgery. In this service, we offer full support in project consultation, ethical permits, module technical support, expert surgeons, animal technicians and data analysis. We can host animals directly or indirectly through collaboration within KU (AKM) and other animal labs. For more information, visit the website: https://ki.se/en/research/research-infrastructure-and-environments/core-facilities-for-research/keric/experimental-surgery

Fondation De Cooperation Scientifique (IHU STRASBOURG)

8 clinical Operating Rooms 5 simulated Operating Rooms (preclinical)

Metropolia Ammattikorkeakoulu Oy (METROPOLIA)

"From home to hospital", Simulated hospital. Rental of the Simulation rooms, audio and video recording. Pre-clinical testing: Helping with research questions (user, customer experience, etc.) Testing the situation as genuinely as possible (Organising skills to create a genuine situation). Helping with the research design and conducting the research, analysis. User testing.

Hospices Civils De Lyon (HCL)

Rental of the surgical facility (130m²), including: - a simulated operating room, with audio-video recording of testing sessions - an observation room with audio-video controls - a meeting room for debriefing, focus group , etc. - a convivial space to welcome participants

Technische Universitaet Muenchen (TUM)

In silico training and optimization: the customer will specify an architecture for software controllers for robotic systems, which will then be deployed in concurrent simulations for e.g., training through reinforcement learning or optimization through genetic algorithms. Performance evaluation of AI-based controllers for robotics based on virtual testing environment: the system provided by the customer, for instance a robotic device using an AI module in closed loop with sensors and actuators for sensorimotor control purposes, will be tested using a simulated environment with sufficient physical realism. Method Description: The Neurorobotics Platform (NRP) is a simulation framework for implementation of highly modular, physically realistic simulations, with a focus on robotics. It also supports the execution of such simulations in the context of an online service on EBRAINS, and can be used in conjunction with standard RL or optimization frameworks. It enables the design, functional evaluation and (at the end of TEF-Health) certification activities for robotic systems, including those with AI modules embedded. Method reference: To be refined depending on the type of task. Either ISO references, scientific literature, work done by WP7, or metrics designed by the TEF-Health consortium.

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Full-scale sleep analysis and sleep staging using polysomnography - Assessment of sleep disorders and disturbances, like sleep apnoea, snoring, restless-leg/arm syndrome, etc. - Analysis of facial expressions during sleep - Contactless measurement of heart rate and respiration

Commissariat A L Energie Atomique Et Aux Energies Alternatives (CEA)

This service provides 2 types of analysis: - Ex vivo imaging study : Multiplex spatial distribution of molecular species in biological tissue - Profiling study: multiplex analysis in complex biological samples. It includes: - Project design & feasibility study - Sample conservation, preparation and analysis using softwares such as Fleximaging & Flexcontrol - Data analysis with provision of a final report Examples: Evaluate or Compare AI system of an IVD-MD to mass spectrometric (MALDI) data of specific animal/human tissue Keywords: Mass Spectrometry; MALDI; ex vivo imaging study; profiling study

Friedrich-Alexander-Universitaet Erlangen-Nuernberg (FAU)

Services: - Full body motion analysis using inertial motion capture, including posturography and pressure distribution - Video-based motion and facial expression analysis - Standardized and reliable gold standard stress induction - Collection of established biopsychological stress markers for further processing - Assessment and analysis of digital biomarkers during stress - Physiological measurements

Hospices Civils De Lyon (HCL)

Summative evaluation of finalized surgical robot prototype (design freeze) in order to validate usability (according to IEC 62366-1). This packaged service includes : - Operating room rental - Participants (healthcare professionals) recruitment within our hospital - Protocol elaboration - User testing organization and moderation - Analysis of collected data from a human factors perspective - Evaluation report including root causes analysis of errors, close calls and use difficulties observed Prices range is indicative and depends on testing protocol complexity and particpants number

Fondazione Istituto Italiano Di Tecnologia (IIT)

This service provides a complete testing setup for gait analysis, motion capture and IEC 10328 compliance for robotic exoskeletons and prostheses. It also provides support and recommendations about how to design and develop robotic rehabilitation systems compliant to IEC 60601-1 standard. Method Description: The service will perform an assessment of wearable robotics solutions (e.g. exoskeletons and prostheses) by using a combination of the following resources: VICON workstation with 12 cameras, sensorized treadmill, force platforms, surface electromyograph, metabolimeter. Method reference: Tests will be based on standards, most notably IEC 10328, when applicable. Otherwise, based on scientific methods for gait analysis. Keywords: robotics; healthcare robotics; prosthesis; orthosis; exoskeleton; testing setup.

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Transcriptome sequencing (RNA-seq) Sequencing of mRNA (poly A based method) followed by fusion detection or germline analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o RNA sequencing (total RNA, mRNA) o Bioinformatics (Bioinformatic analysis on data generated at CG) Equipment Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio)

Centre Hospitalier Universitaire De Grenoble (CHUGA)

Formative evaluation of medical devices: user testing of any medical device prototype in order to improve usability (according to IEC 62366-1). It includes: - writing protocols depending user profiles. - recruitment of required healthcare professionals and patients - rental of the operating room if needed - rental of phantoms - one or several iterative user testing steps and result analyses - evaluation report including ergonomic corrections and guidelines to bring to the medical device

Karolinska Institutet (KI)

The Unit: Clinical Genomics Stockholm (https://www.scilifelab.se/units/clinical-genomics-stockholm/) This infrastructure is part of Science for Life Laboratory (SciLifeLab) which is an academic collaboration between Swedish universities (including Karolinska Institutet) and a national research infrastructure with a focus on life science. Clinical Genomics Stockholm unit is a research infrastructure for large-scale, genomics-based analyses using next generation sequencing technologies. The unit assists in translational research projects, in the translation of genomics-based tools to routine clinical care and also aims to improve the capability for national microbial surveillance and for pandemic preparedness. The Service: Whole genome or targeted DNA sequencing Sequencing of the entire human genome (with a PCR-free protocol) or selected parts of the genome (through exome or panel sequencing), followed by germline or somatic analysis. This service encompasses: o Consultation (Project design, Target capture design) o Sample management o DNA sequencing (Whole Genome Seq (WGS), Whole Exome Seq (WES), Panels) o Bioinformatics (Bioinformatic analysis (data generated at CG) Equipment: Our unit has access to specialized equipment that enable us to factilitate the translation of new high-throughput techniques into clinical use. These include, but are not restricted to: • Various automatic robotic systems (BRAVO NGS Workstation, Hamilton NGS Star) • Various systems for QC, quantification and fragment analyses (TapeStation, Quantification using fluorescent assay (Qubit, Quantit)) • Instrumentation for real time PCR and ddPCR (BioRad qPCR) • Instrumentation for Multispectral imaging (Saphyr optical mapper) • Sequencing platforms: o Illumina (NovaSeq 6000, NovaSeq 6000 Dx, NovaSeq X) o Nanopore (PromethION “access via NGI”) o PacBio (Revio) Prospective Use case: AI based software solution uses WGS data to identify genetic biomarkers to help clinicians either during diagnostic phase and/or at the treatment phase in order to identify genetic aberrations possibly explaining the disease onset or to assist in the therapeutic decisions such as for example in breast cancer the presence of BRCA1 mutation. AI software can be trained to learn to deliver diagnostic based on WGS data (especially needed in the field of rare diseases) to recognize genetic variations (from single nucleotide to over 50bp deletion or insertion) in a more robust and accurate manner (to limit generation of false negative or false positive cases) to support clinicians in their decision process.